Thyroid Peroxidase Antibodies


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Quest Diagnostics Test Code: 5081

In certain instances, the body makes antibodies that can attack the thyroid gland, leading to chronic inflammation causing it to be dysfunctional. The thyroid gland is responsible for the production and release of two principal hormones called T3 and T4. These hormones are responsible for the regulation of metabolism and energy production. When there are antibodies against the thyroid, it can affect the level of these hormones in the blood, leading to disease. Thyroid peroxidase is an enzyme needed to make thyroid hormones. Thyroid peroxidase Antibodies test is done for the presence of Graves disease or Hashimoto thyroiditis.

This test is performed in following conditions such as:

Signs and symptoms of hyperthyroidism
• Weight loss
• Increased heart rate
• Anxiety
• Difficulty sleeping
Signs and symptoms of hypothyroidism
• Weight gain
• Dry skin
• Constipation
• Cold intolerance

Also Known As: TPO Antibodies


It is recommended that someone taking Biotin (also known as vitamin B7 or B8, vitamin H, or coenzyme R) stop consumption at least 72 hours prior to the collection of a sample.


Specimen Collected
  • Blood
Estimated Time Taken

Turnaround time for a Thyroid Peroxidase Antibodies test is typically 1-3 business days.