Histamine Intolerance Test


For: ,

Quest Diagnostics Test Code: 36586

Histamine is a mediator of the allergic response. Histamine release causes itching, flushing, hives, vomiting, syncope, and even shock. In addition, some patients with gastric carcinoids may exhibit high concentrations of histamine.

Histamine is a type of substance that is found in the granules of mast cells and released when these cells are activated, as part of the allergic reaction response. Mast cells are a type of white blood cells that is part of the innate immune system. Histamine is the substance that is responsible for many of the symptoms seen in an allergic reaction. A histamine tolerance test measures the amount of histamine present in the blood. If their level is very high, one usually experiences allergic-type symptoms. This aids in the diagnosis of allergic conditions.

This test is performed in following conditions such as:

• Swelling, itching or irritation around the mouth or throat
• Itchy or watery eyes
• Hives or rash
• Stomach cramps
• Nausea, diarrhea, vomiting
• Difficulty breathing

Also Known As: Plasma


Avoid taking allergy causing drugs, antihistamines, oral corticosteroids and substances which block H2 receptors 24 hours prior to collection.


Specimen Collected
  • Blood
Estimated Time Taken

Turnaround for the Histamine Intolerance test is typically 2-5 business days.