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Quest Diagnostics Test Code: 4021

Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.

Estrogens are a group of steroid hormones that are converted from androgens and are responsible for the development of the secondary sexual characteristics and the functioning of the reproductive organs. Estrogens can be used to diagnose a host of disorders in women depending on the phase of life they are in. There are 3 different types of estrogens that can be measured. This test measures estradiol in the blood. Estradiol is primarily made in the ovaries in women of reproductive age, as well as in the testicles of men. It is the most potent of all the estrogens and is a good marker for ovarian function.

This test is performed in following conditions such as:

• Girls experiencing signs of early or late puberty
• Women experiencing infertility issues
• Women on hormone replacement therapy in menopause
• To assess ovarian function
• In women with irregular menstrual periods
• Symptoms of menopause

Also Known As: E2


For any person for whom low estradiol levels are anticipated (e.g. males and hypogonadal/post-menopausal females), the Estradiol, Sensitive test is the lab-recommended alternative.


Specimen Collected
  • Blood
Estimated Time Taken

Turnaround time for the Estradiol test is typically 1 business day.