Ceruloplasmin

Decreased levels of ceruloplasmin are found in Wilson’s Disease, fulminant liver failure, intestinal malabsorption, renal failure resulting in proteinuria, chronic active hepatitis and malnutrition. Elevated levels are found in primary biliary cirrhosis, pregnancy (first trimester), oral contraceptive use and in acute inflammatory conditions since ceruloplasmin is an acute phase reactant.

Ceruloplasmin is a type of enzyme that is found in the body which has an important role in the metabolism of iron in the body. This enzyme contains copper, which is an important element in energy production, proper functioning of the nervous system and formation of connective tissue. Approximately 95% of the copper in the body can be found in the ceruloplasmin molecule. When copper is not bound to this protein to make ceruloplasmin, it builds up in stores in the liver, brain and other organs. This test is specific for the diagnosis for the rare copper storage disorder called Wilson’s Disease, as well as other diseases like fulminant liver failure and renal failure.

This test is performed in following conditions such as:

• Anemia and fatigue
• Nausea, abdominal pain
• Jaundice
• Tremors
• Difficulty walking