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Quest Diagnostics Test Code: 255

dsDNA Antibody is detected in patients with active systemic lupus erythematosus (SLE) and approximately 20% of patients with Mixed Connective Tissue Disease.

Anti-double stranded DNA (Anti-dsDNA) is an antibody that is found in the blood. Antibodies are proteins that the body makes in order to fight off foreign and harmful materials, such as bacteria and viruses. However, sometimes these antibodies fail to differentiate “self” from “non-self” and these antibodies start breaking down tissue in your body. This is called an auto-antibody. The DNA in the cells of the body are double stranded and this specific antibody targets and damages the DNA in cells. Damage to DNA causes a disruption in the coding of important proteins which then leads to autoimmune disorders such as systemic lupus erythematosus (SLE). Anti-dsDNA is specific to SLE and is used in the diagnosis of the disorder.

This test is performed in following conditions such as:

• Fatigue
• Joint pain
• Fever
• Rash
• Chest pain
• Altered mental status
• Skin sensitivity to light

Also Known As: Antinative DNA, Anti-N-DNA


It is recommended that someone taking Biotin (also known as vitamin B7 or B8, vitamin H, or coenzyme R) stop consumption at least 72 hours prior to the collection of a sample.


Specimen Collected
  • Blood
Estimated Time Taken

Turnaround time for the Anti-dsDNA test is typically 2-3 business days.